Uddin, Md Jalal; Overkleeft, Hermen S.; Lentz, Christian Stephan (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-08-08)
Activity-based protein profiling is a powerful chemoproteomic
technique to detect active enzymes and identify targets and
off-targets of drugs. Here, we report the use of carmofur- and
activity-based probes to identify biologically relevant enzymes
in the bacterial pathogen Staphylococcus aureus. Carmofur is an
anti-neoplastic prodrug of 5-fluorouracil and also has antimicrobial and anti-biofilm ...